Association between PRS and hospitalization status by different methods.

P-value thresholds are indicated for PRSice results, and results are compared to PRS-CS method (last row). PRSice thresholds at P < 5E-8 and 1E-5 are significant at 0.05 level and include a small number of variants indicating low polygenicity (at most 53, after LD clumping with a window-size of 750kb). PRS-CS result is also significant but uses a large number of SNPs. All significant thresholds have positive effect size, indicating that polygenic risk for hospitalization calculated with summary statistics from HGI7no is positively associated with hospitalization in HostSeq. R-squared represents difference in pseudo-R-squared of full model with PRS and null model without PRS.
(XLSX)