B cell-derived IL35 drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer

This study is designed to understand the role of immunosuppressive regulatory B cells (Breg) in pancreatic cancer. Breg and conventional B cells (Bcon) from patients are compared by RNA sequencing analysis. Overall design: Examination of differentially expressed genes in two blood-derived B cell subsets from a Pancreatic Ductal Adenocarcinoma (PAAD) patient.