singleCell Screening of tumor microenvironment after using NRGO@LG+L

Limited immune infiltration in the tumor microenvironment (TME) hampers immune checkpoint blockade (ICB) therapy. Mild photothermal therapy (PTT), enhancing immune infiltration, is often combined with immunotherapy. Nevertheless, the influence of mild PTT on the immune landscape of TME remains uncertain. In this study, we investigated the immune modulation effect of in-situ mild PTT on immune cells in TME by single-cell RNA sequencing (scRNA-seq). From the results, mild PTT significantly influenced the intricate immune systems, leading to the activation of dendritic cells (DCs) and T cells. These observations suggests that immunotherapy could benefit from mild PTT