3D cyto- and receptor architectonic map of macaque intraparietal sulcus area LOP (v1.0)

A multimodal analysis of the macaque intraparietal sulcus was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This project involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey parietal lobe, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 15 different neurotransmitter receptors. The borders of the identified areas were traced onto the macaque stereotaxic space provided by the MEBRAINS and Yerkes 19 templates. We provide here for the first time a map of area LOP of the macaque monkey brain integrating cyto- and receptor architectonic features in stereotaxic space. It constitutes a valuable resource for the analysis of functional experiments with non-human primates, and provides crucial data for modeling approaches with realistic synaptic dynamics.

本研究针对猕猴顶内沟开展多模态分析，旨在构建一套整合既往已发表图谱并调和其间分歧的三维图谱（3D atlas）。本项目采用定量且可经统计学检验的分析方法，对猕猴顶叶的细胞构筑进行研究，并结合体外定量受体放射自显影分析，解析15种不同神经递质受体的区域与层状分布模式。研究人员将已识别脑区的边界标注至由MEBRAINS模板与Yerkes 19模板所提供的猕猴立体定位空间中。本研究首次发布了猕猴大脑LOP脑区的立体定位图谱，该图谱整合了细胞构筑与受体构筑特征。该图谱可为非人灵长类动物的功能实验分析提供宝贵的研究资源，同时也为基于真实突触动力学的建模研究提供关键数据。