A BRD4-mediated elongation control point primes transcribing RNA polymerase II for 3'-processing and termination [nascONT-seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE158964
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资源简介：
In this study, we reveal that BRD4 underlies a general 5'-elongation checkpoint that primes transcribing RNA polymerase II for 3'-RNA processing and transcription termination. BRD4-specific degradation impairs Pol II pause release, induces massive readthrough transcription, and RNA cleavage defects. Acute loss of BRD4 disrupts the recruitment of 3'-RNA processing factors. nascONT-seq of K562 cells treated with DMSO (control) or dBET6
创建时间：
2021-07-31
