Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Arene Core OBHS derivative, phenyl 4,4''-dihydroxy-[1,1':2',1''-terphenyl]-4'-sulfonate

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Arene Core OBHS derivative, phenyl 4,4''-dihydroxy-[1,1':2',1''-terphenyl]-4'-sulfonate Descriptor: Estrogen receptor, Nuclear receptor coactivator 2, phenyl 4,4''-dihydroxy-[1,1':2',1''-terphenyl]-4'-sulfonate Authors: Nwachukwu, J.C, Erumbi, R, Srinivasan, S, Bruno, N.E, Nowak, J, Izard, T, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. Deposit date: 2016-10-13 Release date: 2017-01-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.172 Å) Cite: Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017

与芳烃核心OBHS衍生物苯基4,4""-二羟基-[1,1':2',1""-三联苯]-4'-磺酸盐结合的雌激素受体α（ER-α, Estrogen Receptor alpha）配体结合域（Y537S）的晶体结构
描述符：雌激素受体（Estrogen Receptor）、核受体辅激活因子2（Nuclear receptor coactivator 2）、苯基4,4""-二羟基-[1,1':2',1""-三联苯]-4'-磺酸盐
作者：Nwachukwu, J.C、Erumbi, R、Srinivasan, S、Bruno, N.E、Nowak, J、Izard, T、Kojetin, D.J、Elemento, O、Katzenellenbogen, J.A、Nettles, K.W.
沉积日期：2016-10-13
发布日期：2017-01-18
最后修改日期：2024-03-06
方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.172埃
引用：《配体对ER-α影响的系统结构生物学分析可预测细胞对环境雌激素与抗激素治疗的响应》，《细胞化学与生物学（Cell Chem Biol）》，24卷，2017年