PRR14 mediates mechanotransduction and regulates myofiber identity via MEF2C in skeletal muscle

the expression of TF MEF2C is decreased in skeletal muscle of PRR14-KO mice,which displays sarcopenia phenotype. Meanwhile, increasing MEF2C's expression in skeletal muscle lessens the phenotype. To investigate MEF2C's function in the regulation of skeletal muscle's mass and function, we increased MEF2C's expression through AAV virus in the skeletal muscle of PRR14-KO mice. We then performed gene expression profiling analysis using data obtained from RNA-seq of PRR14-KO skeletal muscle injected with AAV virus for 1 month.