Supplementary Material for: A patient with acute pro-myelocytic leukemia treated with Isotretinoin: A case report

Introducion: ATRA (All-trans retinoic acid) in combination with arsenic trioxide (ATO) is standard therapy for low-to-intermediate risk acute promyelocytic leukemia (APL). Isotretinoin, an agent used for acne vulgaris is similar in its chemical structure and effects to ATRA and single case studies report a probable effectiveness in APL. Case presentation: In this case, a patient with newly diagnosed APL was treated with Isotretinoin/ATO instead of ATRA/ATO for nearly 4 weeks due to a prescription error and anyway reached a stable complete remission as if treated with ATRA/ATO. Conclusion: Treatment of APL with Isotretinoin instead of ATRA could possibly be effective.