Relative Hazards (RH) of starting ART from fitting a Cox regression analysis, according to calendar periods and stratified by type of ADE.

*adjusted for age, gender, nation of birth, mode of HIV transmission,hepatitis co-infection status, type of AIDS diagnosis-all patients model only-,reason for enrolment in Icona, CD4 count and viral load at diagnosis, number of concomitant AIDS diagnoses amycobacteriosis, tubercolosis, Non-Hodgkin lymphomas bisosporidiosis, criptosporidiosis, PML, Kaposi sarcoma andAIDS dementia complex call other ADE