CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITH ALTIRATINIB ANALOG DP-4157

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITH ALTIRATINIB ANALOG DP-4157 Descriptor: Hepatocyte growth factor receptor, N-(2,5-difluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxam ide Authors: Smith, B.D, Kaufman, M.D, Leary, C.B, Turner, B.A, Wise, S.A, Ahn, Y.M, Booth, R.J, Caldwell, T.M, Ensinger, C.L, Hood, M.M, Lu, W.-P, Patt, T.W, Patt, W.C, Rutkoski, T.J, Samarakoon, T, Telikepalli, H, Vogeti, L, Vogeti, S, Yates, K.M, Chun, L, Stewart, L.J, Clare, M, Flynn, D.L. Deposit date: 2015-08-27 Release date: 2016-08-31 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2. Mol.Cancer Ther., 14, 2015

与阿替拉替尼（Altiratinib）类似物DP-4157结合的肝细胞生长因子受体C-MET酪氨酸激酶结构域的晶体结构
描述项：肝细胞生长因子受体，N-(2,5-二氟-4-{[2-(1-甲基-1H-吡唑-4-基)吡啶-4-基]氧基}苯基)-N'-(4-氟苯基)环丙烷-1,1-二羧酰胺
作者：Smith, B.D.、Kaufman, M.D.、Leary, C.B.、Turner, B.A.、Wise, S.A.、Ahn, Y.M.、Booth, R.J.、Caldwell, T.M.、Ensinger, C.L.、Hood, M.M.、Lu, W.-P.、Patt, T.W.、Patt, W.C.、Rutkoski, T.J.、Samarakoon, T.、Telikepalli, H.、Vogeti, L.、Vogeti, S.、Yates, K.M.、Chun, L.、Stewart, L.J.、Clare, M.、Flynn, D.L.
提交日期：2015年8月27日
发布日期：2016年8月31日
最后修改日期：2023年9月27日
检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.6埃（Å）
引用文献：阿替拉替尼通过平衡抑制MET、TIE2与VEGFR2，阻断肿瘤生长、侵袭、血管生成及微环境介导的耐药。《Mol. Cancer Ther.》，14卷，2015年