Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor 1-NA-PP1

Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor 1-NA-PP1 Descriptor: 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, ACETATE ION, Aminoglycoside 3'-phosphotransferase AphA1-IAB, ... Authors: Stogios, P.J, Evdokimova, E, Wawrzak, Z, Minasov, G, Egorova, O, Di Leo, R, Shakya, T, Spanogiannopoulos, P, Todorovic, N, Capretta, A, Wright, G.D, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2012-08-11 Release date: 2012-09-05 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.863 Å) Cite: Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance. Biochem.J., 454, 2013

氨基糖苷磷酸转移酶（aminoglycoside phosphotransferase）APH(3')-Ia的晶体结构，包含底物卡那霉素（kanamycin）与小分子抑制剂1-NA-PP1，其描述信息包括：1-叔丁基-3-(萘-1-基)-1H-吡唑并[3,4-d]嘧啶-4-胺、乙酸根离子、氨基糖苷3'-磷酸转移酶AphA1-IAB等。作者：Stogios, P.J.、Evdokimova, E.、Wawrzak, Z.、Minasov, G.、Egorova, O.、Di Leo, R.、Shakya, T.、Spanogiannopoulos, P.、Todorovic, N.、Capretta, A.、Wright, G.D.、Savchenko, A.、Anderson, W.F.、传染病结构基因组学中心（Center for Structural Genomics of Infectious Diseases, CSGID）；提交日期：2012-08-11，发布日期：2012-09-05，最后修改日期：2024-11-20；实验方法：X射线衍射（分辨率1.863 Å）；引用文献：《通过结构导向优化蛋白激酶抑制剂逆转氨基糖苷类抗生素耐药性》，《生物化学杂志》（Biochem. J.），第454卷，2013年。