Clinical outcomes of high-risk cutaneous squamous cell carcinomas treated with Mohs micrographic surgery alone: an analysis of local recurrence, regional nodal metastases, progression-free survival, and disease.

Clinical outcomes of high-risk cutaneous squamous cell carcinomas treated with Mohs micrographic surgery alone: an analysis of local recurrence, regional nodal metastases, progression-free survival, and disease.

Supplemental Table 1
Patient demographics and high-risk tumor characteristics

Supplemental Table 2
Multivariate Cox regression analysis demonstrating hazard ratios for high-risk tumor characteristics and associations with poor clinical outcomes. Statistically significant findings are highlighted in yellow.

Supplemental Table 3
High-risk features associated with poor outcomes are presented as multivariate Cox proportional hazards models. Tumor features correlating with poor outcomes included size > 2cm, poor differentiation, and perineural invasion. Importantly, multivariate analysis demonstrated that poor differentiation was statistically significant for an increased risk of all poor outcomes – LR, NM, DM, and DSD.

Supplemental Table 4
10-year cumulative incidence comparisons of local recurrence, nodal metastases and disease-specific death for high risk cSCC, stratified by AJCC and BWH stages, with our cohort compared to standardized historic published controls