An axonal guidance cue Semaphorin 6D orchestrates systemic metabolism and myelopoiesis through tuning sympathetic innervation (epididymal white adipose tissue). An axonal guidance cue Semaphorin 6D orchestrates systemic metabolism and myelopoiesis through tuning sympathetic innervation (epididymal white adipose tissue)

The goal of this study is to characterize the molecular basis for enhanced catabolism in Sema6d-/- mice fed a high fat diet. Overall design: WT and Sema6d-/- mice were fed with either control or high fat diet for 3 months. Adipocytes were sorted from the epididymal white adipose tissue.