In vitro study of arsenolipid's effect on the human gut microbial ecosystem, Jun 02 '22. In vitro human gut microbiota

This research used the in vitro mucosal simulator of the human intestinal microbial ecosystem (M-SHIME) to study the effect of defined chemical standards of arsenolipids (AsFA 362 and AsHC 332) on healthy human gut microbiota (n=4). Microbial-derived metabolites were quantified by gas chromatography and microbiota structure was characterized by 16S rRNA gene sequencing. Results suggested a potential detrimental effect of arsenolipids intake on key beneficial gut commensal microorganisms. Hence, the difference of the microbiota composition among individuals is an important factor when considering the health risks of seafood consumption.