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Table S1 - Probing of Exosites Leads to Novel Inhibitor Scaffolds of HCV NS3/4A Proteinase

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Selected inhibitors of HCV NS3/4A. Only the IC50 values below 10 µM are shown. +, the IC50 value of the inhibitor is either in the 10–100 µM or 100–1000 µM range. The HCV NS3/4A activity was measured using the Ac-DE-D(Edans)-EE-Abu-ψ-[COO]AS-K(Dabcyl)-NH2 substrate. SAR indicates the compounds to docking site 3 which have been identified through our SAR efforts. (DOC)
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2012-07-02
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