Expression data from mouse lung alveolar epithelial type II cell with Yap/Taz deletion after bacterial pneumonia-induced lung injury. Mus musculus

To define the role of Yap/Taz in alveolar epithelial regeneration, we deleted Yap/Taz in mouse lung Spc-expressing ATII cells by using Spc-CreERT2, Yap fl/fl, Taz fl/fl, R26R-mTmG mice. This data set contains the microarrays examining gene expression in the lineage-labeled Spc-expressing ATII cells before and after Streptococcus pneumoniae infection. Overall design: We deleted Yap and Taz in the 6-10 weeks old adult mice using the Spc-CreERT2 mouse line. We used S. pneumoniae strain T4 to infect mice by intranasal inhalation at a dose of 2x10E7 CFU. The gene expression analysis was performed on lineage labeled mouse ATII cells isolated by sorting GFP-positive cells from non-injured lung or the lung at 8 days post-SpT4 infection.