Locomotor activity during alternating dark and light periods in zebrafish embryo-larvae exposed to citalopram

Locomotor activity data acquired by infrared individual tracking in a ZebraBox(R) apparatus and ZebraLab software (ViewPoint Life Sciences, Lyon, France) of six days post-fertilization zebrafish (Danio rerio) embryo-larvae exposed to increasing concentrations of the selective serotonin reuptake inhibitor (SSRI) citalopram. The embryo-larvae locomotor activity was tracked during alternating dark (0% illumination) and light periods (100% illumination). The supplied custom R script was used to aggregate, analyze and plot the data. Anxiolytic effects (i.e. hypoactivity during dark conditions) were detected in zebrafish embryo-larvae exposed to citalopram. An associated open access research article can be found at https://www.sciencedirect.com/science/article/pii/S0045653519318119.

本数据集的运动活性数据通过红外个体追踪技术获取，实验依托ZebraBox(R)装置与ZebraLab软件（法国里昂ViewPoint生命科学公司）完成，实验对象为受精后6天的斑马鱼（Danio rerio）胚胎幼体，该幼体暴露于递增浓度的选择性5-羟色胺再摄取抑制剂（selective serotonin reuptake inhibitor，SSRI）西酞普兰。实验过程中，对斑马鱼胚胎幼体的运动活性在交替的黑暗（光照强度0%）与光照（光照强度100%）周期内进行追踪。本数据集附带定制化R脚本，可用于对数据进行汇总、分析与可视化绘图。研究发现，暴露于西酞普兰的斑马鱼胚胎幼体呈现出抗焦虑效应，即黑暗环境下的运动活性降低。相关开放获取研究论文可通过以下链接获取：https://www.sciencedirect.com/science/article/pii/S0045653519318119。