Distinct Long Non-coding RNA Regulatory Architectures Encode Lineage Stability and Epithelial Plasticity

Filename Scientific content Status lncrna_lineage_hematopoietic_pc1.csv 1,410 probe sets driving PC1 (haematopoietic axis). Ranked by |PCA loading|. Loading range: +0.005563 to +0.005774. Shannon entropy: 10.4614 bits. All positive loadings are on the haematopoietic-enriched axis. ✓ Ready lncrna_lineage_brain_pc2.csv 1,410 probe sets driving PC2 (brain/neural axis). Loading range: +0.007709 to +0.010418. Shannon entropy: 10.4589 bits. Mixed probe types: TC=1,041, PSR=289, JUC=7. ✓ Ready lncrna_lineage_breast_pc3.csv 1,410 probe sets driving the PC3 positive pole (breast epithelial axis). Loading range: +0.009501 to +0.013979. Shannon entropy: 10.4570 bits. Widest |loading| range of all four lineages. ✓ Ready lncrna_lineage_endometrium_pc3.csv 1,410 probe sets driving the PC3 negative pole (endometrial axis). Loading range: −0.010876 to −0.005712. Shannon entropy: 10.4503 bits. Negative loadings = endometrium occupies opposite PC3 pole to breast. ✓ Ready summary_statistics.csv Aggregate statistics for all 4 lineages: loading ranges, means, SD, Shannon entropy, and probe-type counts. Machine-readable summary used for Table 1 / Results paragraph. ✓ Ready overlap_matrix.csv 4×4 pairwise intersection matrix. Confirms Brain∩Endometrium=33, all other pairwise=0, and all four=0. Direct evidence for lineage-specificity of regulatory programmes. ✓ Ready brain_endometrium_shared_probes.csv Complete listing of all 33 probe sets shared between Brain (PC2) and Endometrium (PC3), with PC2 loading, PC3 loading, and rank in each list. ✓ Ready README.txt Plain-text description of the entire dataset. Zenodo displays this as the record description. Contains column definitions, method notes, LncExpDB annotation status, source dataset accessions, and citation blocks. ✓ Ready ℹ️ The ENST_transcript_id, RefSeq_accession, gene_symbol, and lncexpdb_validated columns in the four lineage CSV files are currently blank. This is correctly noted in the README.txt. You can update the Zenodo record with annotated versions after completing the LncExpDB lookup step — Zenodo supports versioned updates without losing the DOI.