Gene expression profiles in ethylene glycol-induced renal stone formation and phlorizin treatment

Microarray analysis for total RNA from rat renal cortex and outer meulla. Nephrolithiasis is a disorder with a poor quality of life due to severe pain and no effective medication. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, an anti-diabetic agent, have diuretic and anti-inflammatory effects, suggesting their benefit in treating nephrolithiasis. However, the effects of SGLT2 inhibition against renal stone formation have not been elucidated. To check gene expression profiles, microarray analysis was performed. To evaluate the relationship between SGLT2 inhibition and renal stone formation, renal stone formation rats were generated and treated with phlorizin. Gene expression profiles in the renal cortex and outer medulla were assessed with Clariom S Assays.