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Additional file 2 of Allogeneic MHC-mismatched microglia-like cell replacement as a therapeutic approach for multiple sclerosis

NIAID Data Ecosystem2026-05-10 收录

多发性硬化症细胞治疗

小胶质细胞替代疗法

数据链接：

https://figshare.com/articles/dataset/Additional_file_2_of_Allogeneic_MHC-mismatched_microglia-like_cell_replacement_as_a_therapeutic_approach_for_multiple_sclerosis/31166271 数据链接链接失效反馈

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资源简介：

Supplementary Material 2

应用场景：

创建时间：

2026-01-08

小胶质细胞替代疗法

CSF1R基因编辑

iPSC-derived microglia expressing the wildtype, G795A, or G795C CSF1R variants were generated in vitro and treated with either DMSO or Plexxicon 5622 in order to compare the gene expression difference

NIAID Data Ecosystem50

Engineering an inhibitor resistant human CSF1R variant for microglia replacement [InVivo_RNA]

小胶质细胞替代疗法

神经疾病模型

iPSC-derived hematopoietic progenitor cells expressing either the wildtype or G795A CSF1R variant were xenotransplanted into neonatal mice and subsequently aged for two months to compare in vivo gene

NIAID Data Ecosystem40

Engineering an inhibitor resistant human CSF1R variant for microglia replacement. Engineering an inhibitor resistant human CSF1R variant for microglia replacement

小胶质细胞替代疗法

CSF1R基因工程

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem30

Remyelination is correlated with regulatory T cell induction following human EBNPC transplantation. Homo sapiens

多发性硬化症细胞治疗

髓鞘再生与免疫调节

We have recently described sustained clinical recovery associated with dampened neuroinflammation and remyelination following transplantation of neural precursor cells (NPCs) derived from human embryo

NIAID Data Ecosystem40

Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation

脑转移预防

小胶质细胞替代疗法

Brain metastases are prevalent in various types of cancer and are often terminal, given the low efficacy of available therapies. Therefore, preventing them is of utmost clinical relevance, and prophyl

Figshare2019-04-17 更新30

Additional file 2 of Allogeneic MHC-mismatched microglia-like cell replacement as a therapeutic approach for multiple sclerosis

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