Summary of model of reservoir dynamics and rebound.

a) Patients on fully suppressed ART are given an additional intervention to reduce the LR size. The stochastic model of viral dynamics following ART-interruption tracks both latently infected resting CD4+ T cells (rectangles) and productively infected CD4+ T cells (ovals). Viral rebound occurs if at least one remaining latently infected cell survives long enough to activate and produce a chain of infection events leading to detectable viremia. b) Model predictions for probability that the LR is cleared. Clearance occurs if all cells in the LR die before a reactivating lineage leads to viral rebound. c) Predicted median viral rebound times among patients who do not clear the infection. d) Survival curves (Kaplan-Meier plots) show the percentage of patients predicted to have not yet experienced viral rebound, as a function of the time after treatment interruption.