Developmental regulation of Drosophila dosage compensation in a 3D genome context

Chromosomal dosage compensation (DC) restores the expression balance of X chromosomebetween sexes, and is realised in Drosophila by the coordination of enriched X-linked PionX,HAS sequence elements and 1.6883F satellites, resulting in doubling the transcription ofX-linked genes in males. We study, how DC is dynamically regulated in the different contexts ofgenes, chromatin and cell types, and have broad implications on other DC systems.