Sperm storage causes sperm senescence in human and non-human animals
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In animals, mature sperm are stored in males before ejaculation, and sometimes in females before fertilisation. Sperm storage provides evolutionary advantages; however, storage can also cause sperm deterioration due to post-meiotic sperm ageing. Yet, the extent of such deterioration, the mechanisms driving it, and its consequences remain poorly understood. We perform a meta-analysis across humans (115 studies) and non-human animals (56 studies, 30 species) to understand the impacts of sperm storage. In men, storage via sexual abstinence increases sperm oxidative stress and DNA damage, reduces sperm viability and motility. In other animals, sperm storage in males and females reduces sperm performance and embryo quality. The duration of storage, the method of sampling individuals, and the sperm-storing sex also impact observed outcomes. The results have implications for fertility clinics, sperm selection, captive breeding, and understanding adaptations evolved to mitigate stored-sperm det..., , ## README # Sperm storage causes sperm senescence in human and non-human animals Analysis Software: Rv4.3.1 Packages: tidyverse, BiocManager,TDbook, ggimage,ggtree, ggsankey, ggalluvial, metafor, meta, dplyr, kableExtra, GGally, bookdown, remotes, ggplot2, Matrix, patchwork, ggpubr, rotl, ape, Rcpp, treebase, MCMCglmm, orchaRd, LaplacesDemon, metaviz, matrixcalc, psychmeta, orchaRd, esc, emmeans, DHARMa, lme4, lmerTest, ggpointdensity, viridis, Rmisc, tidytext, ggh4x, hues, rphylopic, ggnewscale, ggimage, tidytree, ggtreeExtra, patchwork, ggforce, ggsankey Data availability: Code and data associated with this project can be found at OSF [https://osf.io/jxv7z/files/osfstorage](https://osf.io/jxv7z/files/osfstorage) with the DOI: 10.17605/OSF.IO/JXV7Z. Note: blank cells in all datasets denote NA, and cells for which data is not applicable or not collected. ### Files 1.     **PMSA_animal_papers_list.xlsx:** File containing data related to screening of animal studies. Variables a....,
在动物界中，成熟精子会在雄性个体体内储存至射精前，有时也会在雌性个体体内储存至受精前。精子储存具备演化优势，但该过程也会因减数分裂后精子衰老引发精子品质劣变。然而，目前学界对这类劣变的程度、驱动机制及其产生的后果仍知之甚少。本研究针对人类（115项研究）与非人类动物（56项研究，涵盖30个物种种群）开展元分析（meta-analysis），以探究精子储存所带来的影响。在人类男性群体中，通过禁欲实现的精子储存会提升精子氧化应激水平与DNA损伤程度，同时降低精子活力与运动能力。在其他动物中，雄性与雌性体内的精子储存均会降低精子性能与胚胎质量。储存时长、个体采样方式以及储存精子的性别，同样会对观测结果产生影响。本研究结果对生殖医学诊所、精子筛选、圈养繁育以及解析为缓解储存精子劣变而演化出的适应机制具有参考意义…… ## README # 精子储存导致人类与非人类动物的精子衰老 分析软件：R 4.3.1 软件包：tidyverse、BiocManager、TDbook、ggimage、ggtree、ggsankey、ggalluvial、metafor、meta、dplyr、kableExtra、GGally、bookdown、remotes、ggplot2、Matrix、patchwork、ggpubr、rotl、ape、Rcpp、treebase、MCMCglmm、orchaRd、LaplacesDemon、metaviz、matrixcalc、psychmeta、orchaRd、esc、emmeans、DHARMa、lme4、lmerTest、ggpointdensity、viridis、Rmisc、tidytext、ggh4x、hues、rphylopic、ggnewscale、ggimage、tidytree、ggtreeExtra、patchwork、ggforce、ggsankey 数据可用性：本项目关联的代码与数据集可在开放科学框架（Open Science Framework, OSF）https://osf.io/jxv7z/files/osfstorage 获取，对应的DOI为10.17605/OSF.IO/JXV7Z。 备注：所有数据集内的空白单元格均代表NA（缺失值），无适用数据或未采集数据的单元格亦同。 ### 文件 1. **PMSA_animal_papers_list.xlsx**：收录动物研究筛选相关数据的文件。 变量：a....,
