STRUCTURE OF KEAP1 KELCH DOMAIN WITH(1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-Yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-Carbonyl]cyclohexane-1-carboxylic acid

STRUCTURE OF KEAP1 KELCH DOMAIN WITH(1S,2R)-2-[(1S)-1-[(1-oxo-2,3-dihydro-1H-isoindol-2-Yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-Carbonyl]cyclohexane-1-carboxylic acid Descriptor: (1S,2R)-2-{[(1S)-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid, ACETATE ION, Kelch-like ECH-associated protein 1 Authors: Smith, M.A, Duclos, S, Beaumont, E, Kwong, J, Brooks, M, Barker, J, Jnoff, E, Brookfield, F, Courade, J.P, Barker, O, Fryatt, T, Albrecht, C, Bromidge, S. Deposit date: 2013-10-03 Release date: 2014-02-19 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex. Chemmedchem, 9, 2014

Kelch样ECH相关蛋白1（Kelch-like ECH-associated protein 1, KEAP1）的Kelch结构域与(1S,2R)-2-[(1S)-1-[(1-氧代-2,3-二氢-1H-异吲哚-2-基)甲基]-1,2,3,4-四氢异喹啉-2-羰基]环己烷-1-羧酸的复合物结构
描述符：(1S,2R)-2-{[(1S)-1-[(1-氧代-1,3-二氢-2H-异吲哚-2-基)甲基]-3,4-二氢异喹啉-2(1H)-基]羰基}环己烷羧酸、乙酸根离子、Kelch样ECH相关蛋白1
作者：Smith, M.A、Duclos, S、Beaumont, E、Kwong, J、Brooks, M、Barker, J、Jnoff, E、Brookfield, F、Courade, J.P、Barker, O、Fryatt, T、Albrecht, C、Bromidge, S.
入库日期：2013-10-03
发布日期：2014-02-19
最后修改日期：2024-10-16
实验方法：X射线衍射（分辨率2.55埃）
引用文献：《Nrf2-KEAP1复合物直接抑制剂的结合模式与构效关系》，发表于《Chemmedchem》2014年第9卷