Gene expression in adult male and female mouse liver was assayed by RNA-seq, as part of a study on hepatic lincRNAs. Overall design: Total liver RNA was prepared from 12 individual male and 12 individ

NIAID Data Ecosystem50

Transgenerational epigenetic and transcriptomic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in rat [array]

表观遗传毒性

肝脏转录组

In rats, direct exposure to TCDD causes myriad toxicities. Exposed rats experience hepatotoxicity, wasting syndrome and immune suppression, amongst others. “Inherited exposure”, as occurs in the F3 ge

Alliance of Genome Resources20

Fmo5(-/-) mouse: liver transcriptomics

肝脏转录组

基因敲除表型分析

We report the consequences of the disruption of the Fmo5 gene on transcription of genes in liver. Comparison of liver gene expression in wild-type and Fmo5(-/-) mice

NIAID Data Ecosystem70

GH directly inhibits steatosis and liver injury in a sex-dependent and IGF1-independent manner. GH directly inhibits steatosis and liver injury in a sex-dependent and IGF1-independent manner

非酒精性脂肪性肝病机制

肝脏转录组

A reduction in hepatocyte growth hormone (GH)-signaling promotes non-alcoholic fatty liver disease (NAFLD). However, debate remains as to the relative contribution of the direct effects of GH on hepat

NIAID Data Ecosystem40

Epigenetic and transcriptomic signature of aging in human liver [expression]

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