SARS-CoV-2 Spike Mutation Frequencies: A High-Resolution Dataset for mAb and Vaccine Design

This dataset provides precise, large-scale frequency counts for 25 key SARS-CoV-2 spike mutations including T478K (7.48M), N501Y (5.26M), L452R (4.15M), and F486V (1.09M) all mapped from 10 million+ of global sequences. These residues directly overlap major neutralizing antibody epitopes; their prevalence signals real-world immune escape pressure. n= 10 M+ Span: 2020 upto Q1 2025 This dataset shows essential intelligence on which variants are not just emerging, but already dominant. Analysis Summary: F486P: 593861 sequencesS371F: 3027840 sequencesK444T: 234300 sequencesN460K: 876375 sequencesR346T: 760668 sequencesG339D: 3981740 sequencesS375F: 4515633 sequencesE484A: 4337265 sequencesQ493R: 2825437 sequencesL452R: 4156295 sequencesV445P: 361460 sequencesF490S: 401519 sequencesQ498R: 4519617 sequencesY505H: 4521293 sequencesT478K: 7485748 sequencesS373P: 4523173 sequencesN440K: 4004704 sequencesD405N: 3113907 sequencesR408S: 2982186 sequencesE484K: 322953 sequencesK417N: 4044885 sequencesG446S: 1811681 sequencesS477N: 4621927 sequencesN501Y: 5261406 sequencesF486V: 1093102 sequences Dataset prepared & processed by [e-mail]