Crystal structure of human phenylethanolamine N-methyltransferase (PNMT) in complex with (2S)-2-amino-4-(((5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(4-(7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-4-yl)butyl)amino)butanoic acid and AdoHcy (SAH)

Crystal structure of human phenylethanolamine N-methyltransferase (PNMT) in complex with (2S)-2-amino-4-(((5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(4-(7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-4-yl)butyl)amino)butanoic acid and AdoHcy (SAH) Descriptor: 1,2-ETHANEDIOL, 5'-([(3S)-3-amino-3-carboxypropyl]{4-[(4R)-7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-4-yl]butyl}amino)-5'-deoxyadenosine, CADMIUM ION, ... Authors: Harijan, R.K, Mahmoodi, N, Minnow, Y.V.T, Bonanno, J.B, Almo, S.C, Schramm, V.L. Deposit date: 2022-02-07 Release date: 2023-02-15 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Cell-Effective Transition-State Analogue of Phenylethanolamine N -Methyltransferase. Biochemistry, 62, 2023

人类苯乙醇胺N-甲基转移酶（phenylethanolamine N-methyltransferase, PNMT）与(2S)-2-氨基-4-(((5-(6-氨基-9H-嘌呤-9-基)-3,4-二羟基四氢呋喃-2-基)甲基)(4-(7,8-二氯-1,2,3,4-四氢异喹啉-4-基)丁基)氨基)丁酸及腺苷高半胱氨酸（AdoHcy, SAH）结合的晶体结构。描述项：1,2-乙二醇、5'-([(3S)-3-氨基-3-羧丙基]{4-[(4R)-7,8-二氯-1,2,3,4-四氢异喹啉-4-基]丁基}氨基)-5'-脱氧腺苷、镉离子……。作者：Harijan, R.K.、Mahmoodi, N.、Minnow, Y.V.T.、Bonanno, J.B.、Almo, S.C.、Schramm, V.L.。提交日期：2022-02-07；发布日期：2023-02-15；最后修改日期：2024-11-06。实验方法：X射线衍射（2.1 Å）。引用文献：《苯乙醇胺N-甲基转移酶的细胞级有效过渡态类似物》，《生物化学》，第62卷，2023年。