Data for: Association between polymorphism in Cyclophilin A gene and its serum and placental expression in Han Chinese women with severe preeclampsia

According to the time of onset, the severe PE patients were further divided into early onset (diagnosis of PE at < 34 weeks) PE subgroup (n = 38) and late onset (diagnosis of PE at ≥ 34 weeks) PE subgroup (n = 44). Maternal serum CypA levels were dectected in 48 severe PE patients (22 early onset PE and 26 late onset PE) and 40 healthy pregnancies by age matching method from the samples for genotyping. 40 placenta tissues from 20 severe PE patients (11 early onset PE and 9 late onset PE) and 20 age matched healthy controls were chosed for mRNA and protein detection. Clinical characteristics of these subgroups were analyzed in the supplementary tables.

根据发病时间，将重度子痫前期（PE）患者进一步划分为早发型亚组（孕<34周确诊PE，样本量n=38）与晚发型亚组（孕≥34周确诊PE，样本量n=44）。本研究从用于基因分型的存档样本中，采用年龄匹配策略筛选出48例重度PE患者（其中早发型PE 22例、晚发型PE 26例）及40例健康妊娠女性的血清标本，对其母体血清中的亲环素A（CypA）水平开展检测。另选取20例重度PE患者（含11例早发型PE、9例晚发型PE）与20例年龄匹配的健康对照者的胎盘组织共40份，用于mRNA与蛋白质水平的检测。上述各亚组的临床特征分析结果详见补充附表。