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The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores.

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DNA复制检查点

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数据链接：

https://www.yeastgenome.org/dataset/GSE30024 数据链接链接失效反馈

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Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity

应用场景：

DNA复制检查点

细胞周期调控

DNA replication checkpiont kinase rad3 (human ATM/ATR-like kinase) and cds1 (human CHK2-like kinase) are known to restore stalled replication forks and prevent subsequent cell cycle progression during

NIAID Data Ecosystem60

Targeting transcription-replication conflicts is an effective therapeutic principle for MYCN-driven neuroblastoma [4SU-seq]

MYCN驱动神经母细胞瘤

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Targeting the function of MYC proteins for therapy is a major challenge in tumor biology. MYC proteins are transcription factors that can globally release RNA polymerase II (RNAPII) from core promoter

NIAID Data Ecosystem40

Recombination frequencies of selected candidates.

R-loop代谢调控

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Transcription is essential for cellular function, but it can also lead to genetic instability, particularly through the formation of secondary structures such as R-loops, which consist of an RNA-DNA h

NIAID Data Ecosystem20

Mobile origin-licensing factors confer resistance to conflicts with RNA polymerase. Scherr et al (Part 4)

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DNA复制起始许可

Mobile origin-licensing factors confer resistance to conflicts with RNA polymerase Part 4. Raw microscopy data contained in separate zip files. Each file contains tif images collected with MicroManag

NIAID Data Ecosystem40

The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition

细胞周期调控

DNA复制检查点

It has been proposed that ATR kinase senses the completion of DNA replication to initiate the S/G2 transition. In contrast to this model, we show here that the TRESLIN-MTBP complex prevents a prematur

NIAID Data Ecosystem30

The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores.

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