Structure of CLK1 with bound N-methyl-10-nitropyrido[3,4-g]quinazolin-2-amine

Structure of CLK1 with bound N-methyl-10-nitropyrido[3,4-g]quinazolin-2-amine Descriptor: Dual specificity protein kinase CLK1, POTASSIUM ION, ~{N}-methyl-10-nitro-pyrido[3,4-g]quinazolin-2-amine Authors: Joerger, A.C, Chatterjee, D, Schroeder, M, Tazarki, H, Zeinyeh, W, Esvan, Y.J, Khiari, J, Josselin, B, Baratte, B, Bach, S, Ruchaud, S, Anizon, F, Giraud, F, Moreau, P, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2018-12-15 Release date: 2019-02-20 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3 Å) Cite: New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis. Eur J Med Chem, 166, 2019

CLK1结合N-甲基-10-硝基吡啶并[3,4-g]喹唑啉-2-胺的结构
描述：双特异性蛋白激酶CLK1、钾离子、N-甲基-10-硝基吡啶并[3,4-g]喹唑啉-2-胺
作者：Joerger, A.C.、Chatterjee, D.、Schroeder, M.、Tazarki, H.、Zeinyeh, W.、Esvan, Y.J.、Khiari, J.、Josselin, B.、Baratte, B.、Bach, S.、Ruchaud, S.、Anizon, F.、Giraud, F.、Moreau, P.、Knapp, S.，结构基因组学联合体（Structural Genomics Consortium, SGC）
存档日期：2018-12-15
发布日期：2019-02-20
最后更新日期：2024-01-24
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率3 Å
引用文献：《新型吡啶并[3,4-g]喹唑啉衍生物作为CLK1与DYRK1A抑制剂：合成、生物学评价及结合模式分析》，刊载于《欧洲药物化学杂志》（Eur J Med Chem）2019年第166卷