Crystal structure of serine hydroxymethyltransferase from Mycobacterium tuberculosis with bound PLP forming a Schiff base with substrate Serine in one monomer and PLP forming a Schiff base with product Glycine in the other monomer

Crystal structure of serine hydroxymethyltransferase from Mycobacterium tuberculosis with bound PLP forming a Schiff base with substrate Serine in one monomer and PLP forming a Schiff base with product Glycine in the other monomer Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCINE, PYRIDOXAL-5'-PHOSPHATE, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2019-10-07 Release date: 2019-10-16 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of serine hydroxymethyltransferase from Mycobacterium tuberculosis with bound PLP forming a Schiff base with substrate Serine in one monomer and PLP forming a Schiff base with product Glycine in the other monomer to be published

结核分枝杆菌（Mycobacterium tuberculosis）来源的丝氨酸羟甲基转移酶晶体结构，其结合的吡哆醛-5'-磷酸（pyridoxal-5'-phosphate, PLP）在一个单体中与底物丝氨酸形成希夫碱，在另一单体中与产物甘氨酸形成希夫碱。描述符：(4S)-2-METHYL-2,4-PENTANEDIOL、甘氨酸、吡哆醛-5'-磷酸…… 作者：西雅图传染病结构基因组学中心（Seattle Structural Genomics Center for Infectious Disease, SSGCID） 提交日期：2019-10-07 发布日期：2019-10-16 最后修改日期：2023-10-11 实验方法：X射线衍射（分辨率1.5 Å） 引用说明：结核分枝杆菌来源的丝氨酸羟甲基转移酶晶体结构，其一单体结合的PLP与底物丝氨酸形成希夫碱，另一单体中的PLP与产物甘氨酸形成希夫碱，待发表。