Main results from the statistical analysis of behavioral data.

Behavioral tests were carried out on animals that had been exposed in the adolescent period to increasing doses of THC (2.5, 5 and 10 mg/kg or vehicle) from pnd 28 to 45 and to MDMA (10 mg/kg or saline) twice daily every 5 days from pnd 30 to 45 (see text for details). Three-way ANOVA analyses were performed, except for on the closed arm entries, with factors being sex (males vs. females), neonatal manipulation (control vs. MD) and drug treatment (Sal vs. Coc). The main statistical values are shown: F, with degrees of freedom, or H (in the case of Kruskal-Wallis) for closed arm entries, and p-values. Non-significant results are not included (−). Behavioral tests: HB, holeboard test; EPM, elevated plus maze; OF, open field; NOT, novel object test; PPI, prepulse inhibition test.