Computed Tomography of Diverse, Genotyped Dogs

The domestic dog (Canis familiaris) is one of the world’s most morphological diverse animal species. The diversity observed in dogs manifests both in terms of allometry (shape effects due to size) and size-independent traits. The Schoenebeck group and their collaborators leveraged computed tomography scans to quantify morphological differences as phenotype for genome wide association. Here we provide the raw computed tomography scans of dogs used in our genome-wide mapping studies. These data will provide a morphological overview of modern canine skull morphology. Coupled with their genotypes, this dataset will enable QTL mapping to elucidate novel genes and genetic variants that are likely relevant to understanding the genetic basis of human craniofacial anomalies.家犬（Canis familiaris）是全球形态多样性最为突出的动物物种之一。家犬所呈现的形态多样性，同时涵盖异速生长（allometry，即由体型差异导致的形状效应）与不依赖体型的性状两类维度。舍内贝克（Schoenebeck）课题组及其合作团队借助计算机断层扫描（computed tomography）技术，将犬类的形态差异量化为表型，用于全基因组关联分析研究。本研究公开了课题组在全基因组定位研究中使用的家犬原始计算机断层扫描数据。该数据集可系统呈现现代家犬的颅骨形态全貌。结合这些家犬的基因型数据，本数据集可用于数量性状位点（QTL）定位，进而阐明与解析人类颅面畸形遗传基础相关的全新基因及遗传变异。