4D-DIA Proteomics Uncovers New Insights into Host Salivary Response Following SARS-CoV-2 Omicron Infection

We applied a 4D dia-PASEF proteomic approach to investigate the salivary protein profile of individuals with early-to-acute SARS-CoV-2 Omicron infection. We combined proteomics and functional analyses with feature selection and ROC multivariate analysis to identify and assess salivary proteins for COVID-19 screening.