Omics-Lethal Human Viruses, Influenza A Experiment IM102

The purpose of this experiment was to evaluate the host response to wild-type Influenza A/Anhui/1/2013 (H7N9; "AH1-WT") virus and mutant viruses NS1-103F/106M ("AH1-F/M") and partially ferret-adapted ("AH1-691") infection. Sample data was obtained from mouse lung tissue and processed for mRNA, miRNA, proteomics, metabolomics, and lipidomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset download each have a direct relationship to a primary sample submission corresponding to a specific Influenza A virus infection.

本实验旨在评估宿主对野生型甲型流感病毒A/Anhui/1/2013（H7N9；“AH1-WT”）、突变株NS1-103F/106M（“AH1-F/M”）以及部分经雪貂适应的（“AH1-691”）病毒感染的应答反应。样本数据取自小鼠肺组织，经处理后用于mRNA、微小RNA（miRNA）、蛋白质组学（proteomics）、代谢组学（metabolomics）及脂质组学（lipidomics）的表达分析。二级宿主相关病毒数据集下载项包含经统计学处理（含归一化、数据转换）的定量数据集集合，可用于开展宿主-病原体原始实验研究设计的定性表达分析。依托独有的高分辨率组学（Omics）技术，蛋白质组学、代谢组学、脂质组学与转录组学（transcriptomics）的数据集下载项，均与对应特定甲型流感病毒感染的原始样本提交存在直接关联。