DBDPE induces more persistent disturbances than BDE-209 in Crassostrea gigas: Gut microbiome-modulated physiological responses

Decabromodiphenyl ether (BDE-209) and its alternative, decabromodiphenyl ethane (DBDPE), are brominated flame retardants (BFRs) globally distributed in marine environments, posing risks to marine organisms. The gut microbiome not only degrades BFRs but also undergoes BFR-induced compositional and host-microbe co-metabolic changes. This study provides comprehensive insights into gut microbiome and metabolome responses to BDE-209 and DBDPE, elucidating recovery mechanisms and the mediating role of gut microbiome in BFR-induced adverse effects in oysters.