Structural, Computational and Kinetic Data for Antifolate Interactions Against Pneumocystis jirovecii, Pneumocystis carinii and Human Dihydrofolate Reductase and Their Active Site Mutants

Structural, Computational and Kinetic Data for Antifolate Interactions Against Pneumocystis jirovecii, Pneumocystis carinii and Human Dihydrofolate Reductase and Their Active Site Mutants Descriptor: 6-{[(2,5-dichlorophenyl)amino]methyl}pyrido[2,3-d]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Cody, V. Deposit date: 2009-12-17 Release date: 2011-01-05 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants. Antimicrob.Agents Chemother., 57, 2013

抗叶酸剂与耶氏肺孢子菌（Pneumocystis jirovecii）、卡氏肺孢子菌（Pneumocystis carinii）及人二氢叶酸还原酶（dihydrofolate reductase, DHFR）及其活性位点突变体的相互作用结构、计算与动力学数据集。描述物：6-{[(2,5-二氯苯基)氨基]甲基}吡啶并[2,3-d]嘧啶-2,4-二胺、二氢叶酸还原酶、还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）等。作者：Cody, V. 提交日期：2009年12月17日；发布日期：2011年1月5日；最后修改日期：2023年9月6日。实验方法：X射线衍射（分辨率2埃）。引用文献：《针对耶氏肺孢子菌、卡氏肺孢子菌及人二氢叶酸还原酶及其活性位点变体的强效抗叶酸抑制动力学与结构分析》，《抗菌剂与化疗》（Antimicrob. Agents Chemother.），第57卷，2013年。