Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001580

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001580 Descriptor: 1-[2-({3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propyl}amino)phenyl]piperidine-4-carboxylic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2020-10-23 Release date: 2021-07-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001580 to be published

溃疡分枝杆菌Agy99（Mycobacterium ulcerans Agy99）来源的二氢叶酸还原酶（Dihydrofolate reductase, DHFR）与烟酰胺腺嘌呤二核苷酸磷酸（NADP，NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE）及抑制剂SDDC-0001580形成复合物的晶体结构。描述信息：抑制剂为1-[2-({3-[(2,4-二氨基-6-乙基嘧啶-5-基)氧基]丙基}氨基)苯基]哌啶-4-羧酸，相关组分包含二氢叶酸还原酶与烟酰胺腺嘌呤二核苷酸磷酸。作者：西雅图传染病结构基因组学中心（Seattle Structural Genomics Center for Infectious Disease, SSGCID）。提交日期：2020-10-23。发布日期：2021-07-07。最后修改日期：2023-10-18。实验方法：X射线衍射（分辨率1.25埃）。引用说明：溃疡分枝杆菌Agy99来源的二氢叶酸还原酶（DHFR）与NADP及抑制剂SDDC-0001580形成的复合物晶体结构，待发表。