Original data of the article entitled “YB-1 recruits Drosha to promote splicing of pri-miR-192 to mediate the proangiogenic effects of H2S.” Zhou Y et al

miR-192 has a central role for the cells to sense the proangiogenic signals of H2S. The study reveals a new mechanism to regulate microRNA biosynthesis at the primary-to-precursor step in sensing H2S. In addition to H2S donors, the study provides some new potential targets deserves to be explored for anti-ischemia therapies, e.g., approaches based on regulating CSE and miR-192 The file named Zhou Y et al miRNAarray data 20200514 includes the microarray profiling of microRNAs showed a preliminary pattern of changes in the vascular endothelial cells treated with H2S. The file named Zhou Y et al Western Blot data 20200514 includes unedited images for all blots shown in the manuscript.

微小RNA-192（miR-192）在细胞感知硫化氢（H2S）的促血管生成信号过程中发挥核心作用。本研究揭示了一条全新的调控机制，可在细胞感知硫化氢的过程中，于微小RNA生物合成的初级转录本至前体阶段调控其生物合成过程。除硫化氢供体外，本研究还为抗缺血治疗提供了若干值得深入探索的潜在新靶点，例如基于调控胱硫醚γ裂解酶（CSE）与miR-192的干预策略。文件"Zhou Y et al miRNAarray data 20200514"收录了微小RNA微阵列谱数据，该数据呈现了经硫化氢处理的血管内皮细胞中微小RNA的初步变化模式。文件"Zhou Y et al Western Blot data 20200514"包含了本研究手稿中展示的所有免疫印迹条带的未编辑原始图像。