Psen2

ENCODES a protein that exhibits aspartic endopeptidase activity, intramembrane cleaving (ortholog); endopeptidase activity (ortholog); INVOLVED IN response to hypoxia; amyloid precursor protein catabolic process (ortholog); amyloid-beta formation (ortholog); PARTICIPATES IN altered Notch signaling pathway involving the macromolecules modifying the main players; Alzheimer's disease pathway; Notch signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 4 (ortholog); asphyxia neonatorum (ortholog); FOUND IN early endosome; presynaptic membrane; synaptic membrane; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene

编码一种表现出天冬氨酸内肽酶活性的蛋白质，膜内裂解（同源）；内肽酶活性（同源）；参与对缺氧的反应；淀粉样蛋白前体蛋白代谢过程（同源）；淀粉样-β形成（同源）；参与涉及调节主要参与者的大分子改变的变异 notch 信号通路；阿尔茨海默病通路；Notch 信号通路；与阿尔茨海默病（同源）；阿尔茨海默病4（同源）；新生儿窒息（同源）；存在于早期内体；突触前膜；突触膜；与（+）五味子素B；2,3,7,8-四氯二苯并-对二恶英；2,6-二硝基甲苯相互作用。