Compound characteristics. Cpd1 is the same as DGAT1i in Lin, H et al (2013) [4], while Cpd2 is the same as Compound L in Liu, J et al (2013) [3].

Plasma = plasma concentration; Skin = skin concentration; Skin/Plasma Ratio = skin to plasma concentration ratio; Fu Plasma = unbound fraction in plasma; mlogD = measured logD; clogD = calculated logD using ACD (measure of lipophilicity); mDGAT1 IC50 = in vitro potency; Skin/IC50 = skin concentration vs in vitro potency; Scoring = histological adverse effect score; clogD/mIC50 = calculated logD vs in vitro potency; BLQ = below detection. Bold = compounds causing atrophy.