Genomics of Glomerular Disorders

The purpose of the "Genomics of Glomerular Disorders" study is to identify genetic contributions to primary glomerulopathies. This repository includes a total of N = 4,238 patients with a kidney biopsy diagnosis of a primary glomerular disorder across the following categories: focal segmental glomerulosclerosis (FSGS, N = 583), Henoch-Schönlein purpura nephritis (HSPN, N = 403), IgA nephropathy (IgAN, N = 1,555), membranous nephropathy (MN, N = 1,003), and minimal change disease (MCD, N = 694). The dataset includes a total of 2,290 patients recruited into the Cure Glomerulonephropathy (CureGN) study and another 1,948 patients from the Columbia University CKD Biobank (i.e., non-CureGN patients). The sample sizes by phenotype are counted based on enrollment diagnoses. The repository includes 3,958 WGS samples and 2,129 RNA-seq samples.]]>
Participants of the study must be diagnosed with MCD, FSGS, MN, or IgAN via diagnostic kidney biopsy within 5 years of study enrollment. Additionally, participants must have access to the results and/or slides of their first kidney biopsy. Individuals are excluded from the study if they are an institutionalized patient; an organ or bone marrow transplant recipient; have end stage kidney disease; or have diagnosed cancer, Hepatitis B, Hepatitis C, HIV, diabetes mellitus, or systemic lupus erythematosus.]]>