The clinical efficacy of minocycline mouth rinses on recurrent aphthous stomatitis – A randomized controlled trial.

Introduction: Recurrent aphthous stomatitis (RAS) is one of the most common ulcerative diseases affecting the general population. The present study aimed to evaluate the clinical efficiency of 0.5% minocycline mouth rinses prescribed along with the topical anesthetic gel and vitamin supplements over the topical anesthetic gels and vitamin supplements prescribed alone for treating RAS. Materials and methods: A total of sixty participants were randomly divided into two groups, Experimental group: 0.5% Minocycline mouth rinses prescribed along with vitamin supplements and topical anesthetic gel and Control group: Vitamin supplements and topical anesthetic gels alone. The pain symptoms were evaluated using the VAS scores at baseline, and first follow-up visits. The data were analyzed using student t-test. Results: A significant reduction in the pain scores was observed in participants using the 0.5% minocycline mouth rinses prescribed along with vitamin supplements and topical anesthetic gel on the first follow-up visit (p = <0.001). Conclusion: The 0.5% minocycline mouth rinses prescribed along with vitamin supplements and topical anesthetic gel had shown more reduction in the pain symptoms when compared to topical anesthetic gels and vitamin supplements prescribed alone for the treatment of RAS.

引言：复发性阿弗他口炎（Recurrent aphthous stomatitis, RAS）是影响普通人群最常见的溃疡性疾病之一。本研究旨在评估0.5%米诺环素含漱液联用局部麻醉凝胶与维生素补充剂，相较于单独使用局部麻醉凝胶及维生素补充剂治疗复发性阿弗他口炎的临床疗效。
材料与方法：本研究共纳入60名受试者，随机分为两组。实验组：0.5%米诺环素含漱液联合维生素补充剂与局部麻醉凝胶；对照组：仅使用维生素补充剂与局部麻醉凝胶。分别于基线及首次随访时采用视觉模拟评分法（Visual Analogue Scale, VAS）评估疼痛症状，采用学生t检验对数据进行统计分析。
结果：在首次随访时，使用0.5%米诺环素含漱液联合维生素补充剂与局部麻醉凝胶的受试者疼痛评分出现显著降低（p < 0.001）。
结论：相较于单独使用局部麻醉凝胶及维生素补充剂，0.5%米诺环素含漱液联合维生素补充剂与局部麻醉凝胶可更显著地缓解复发性阿弗他口炎患者的疼痛症状。