Transcriptome Analyses Differentially Expressed Genes In Granulosa cells from female with Metabolic Syndrome

Metabolic syndrome (MS), characterized by a constellation of metabolic abnormalities including insulin resistance, obesity, dyslipidemia, and hypertension, has emerged as a significant public health concern globally . The underlying mechanisms by which MS contributes to infertility remain not entirely understood, impeding the development of effective diagnostic and therapeutic strategies. Granulosa cells (GCs) are pivotal in the ovarian folliculogenesis process, playing essential roles in the maturation of oocytes and the orchestration of hormonal signals necessary for successful reproduction .