DNA Inverted Repeats as an At-risk Motif for Palindromic Gene Amplification

DNA Inverted Repeats as an At-risk Motif for Palindromic Gene Amplification defines oncogene amplification that is configured as a series of inverted duplications (palindromic gene amplification). To study the impact of palindromic gene amplification in cancer genomes, we developed an approach to enrich DNA palindromes from genomic DNA (Genome-wide Analysis of Palindrome Formation, GAPF-seq). This dbGaP site lists the files of GAPF-seq of tumor DNA and plasma DNA from cancer patients. This site also lists other genomic data, such as shallow whole-genome sequencing (WGS) data. WGS data were used to examine the association of DNA palindromes, detected by GAPF-seq, and genomic amplification, detected by WGS. In the initial study, we show that the ERBB2 oncogene at 17q12 is susceptible to... (for more see dbGaP study page.)