Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state)

Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, CHOLESTEROL, ... Authors: Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I. Deposit date: 2023-05-08 Release date: 2023-09-06 Last modified: 2024-10-09 Method: ELECTRON MICROSCOPY (2.72 Å) Cite: Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023

结合竞争性拮抗剂ZK与抗癫痫药物吡仑帕奈（perampanel）的辅助亚基TARPγ-5（Transmembrane AMPA Receptor Regulatory Protein γ-5）复合的AMPA受体GluA2的配体结合域-跨膜结构域（LBD-TMD）复合物结构（闭合状态）
组成组分：1,2-二油酰-sn-甘油-3-磷酸胆碱、2-(6'-氧代-1'-苯基[1',6'-二氢[2,3'-联吡啶]]-5'-基)苄腈、胆固醇，……
作者：Gangwar, S.P.、Yen, L.Y.、Yelshanskaya, M.V.、Sobolevsky, A.I.
存档日期：2023-05-08
发布日期：2023-09-06
最后修改日期：2024-10-09
实验方法：电子显微镜（分辨率2.72 Å）
引用文献：《辅助亚基cornichon-2对GluA2-γ5突触复合物的脱敏、多胺阻滞及抗癫痫药物吡仑帕奈抑制作用的调控》，《自然·结构与分子生物学》（Nat.Struct.Mol.Biol.），第30卷，2023年