A detailed proteomic analysis of plasma membrane from zebrafish brain

The brain plasma membrane proteome represents the major subsets of signaling proteins and promising drug targets though often understudied due to traditional experimental difficulties. Here we report a comprehensive dataset of the proteins identified in the highly enriched plasma membrane of zebrafish brain by applying multidimensional liquid chromatography coupled with tandem-mass spectrometry (MS/MS). A total number of 108767 peptide groups were identified resulting in 9201 proteins. These included brain receptors, transporters and channels that are important elements linked to brain functions, diseases and drug discovery.