Crystal toxin triggered necrosis pathway

This pathway is modeled on a description provided in Zhang et al. under the title "A deficiency in the necrosis pathway confers tolerance to Cry6Aa". Cry6Aa binds to the calcium channel ITR-1 and increases intracellular Ca2+ levels. Ca2+ binds to and activates Calpain TRA-3 which promotes cysteine protease activity. Cysteine Protease activates VHA-12 that uses ATP to increase pH of the cytosol. The increase in H+ concentration signals to the ASP-1/ASP-3/ASP-4 complex which leads to activation of killer cathepsin protease and leads to cell necrosis.

本路径模型基于 Zhang 等人在标题为 'A deficiency in the necrosis pathway confers tolerance to Cry6Aa' 的论文中提供的描述。Cry6Aa 结合钙通道 ITR-1 并增加细胞内 Ca2+ 水平。Ca2+ 结合并激活 Calpain TRA-3，进而促进半胱氨酸蛋白酶的活性。半胱氨酸蛋白酶激活 VHA-12，该酶利用 ATP 增加细胞质 pH 值。H+ 浓度的增加向 ASP-1/ASP-3/ASP-4 复合体发出信号，导致杀伤性猫蛋白酶蛋白酶的激活，进而引发细胞坏死。