Titanium(IV)-Mediated Conversion of Carboxamides to Amidines and Implications for Catalytic Transamidation

Cp*-ligated imidotitanium(IV) complexes,
Cp*TiCl(NR)(py)Cl (R = tBu (5a), PhCH2 (5b), n-C5H11
(5c), p-MeC6H4 (5d), p-MeOC6H4 (5e)), react with tertiary and secondary carboxamides to yield amidines, a
result that is in contrast with previously reported
titanium-catalyzed transamidation reactions. The tertiary amide dimethylacetamide reacts directly with the
imidotitanium(IV) fragment, whereas the secondary
amide phenylacetamide forms an amidate adduct, {(η5-C5Me5)TiCl[OC(Me)NPh]2} (10), which undergoes subsequent reaction with exogenous amine.