Preparative-Scale Synthesis of Vedejs Chiral DMAP Catalysts
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https://figshare.com/articles/dataset/Preparative-Scale_Synthesis_of_Vedejs_Chiral_DMAP_Catalysts/7188968
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资源简介：
A scalable synthesis of chiral Vedejs-type
DMAP catalysts is reported.
The key step of the synthesis is amination of the enantiomerically
pure 4-chloropyridine derivative using well-defined ZnCl2(amine)2 complexes. A series of Zn(II)–amine complexes
have been synthesized to explore the scope of the ZnCl2-mediated amination of 4-halopyridines. Mechanistic studies support
a Zn(II)-facilitated nucleophilic aromatic substitution as a plausible
mechanism for the chlorine-to-amine exchange.
创建时间：
2018-10-10
